The Anti-REG3B Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody to Reg3b, and regenerating islet-derived 3 beta. This antibody recognizes Mouse antigen. The Anti-REG3B Antibody, Rabbit Polyclonal has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis